‘The Second Best Hospital In The Galaxy’ Adds Bowen Yang, Tracee Ellis Ross, John Waters, & More; Watch The Trailer

Prime Video has set the guest cast and released the trailer for The Second Best Hospital in the Galaxy, its adult animated sci-fi comedy from Cirocco Dunlap and Maya Rudolph, Danielle Renfrew Behrens and Natasha Lyonne‘s Animal Pictures. Tracee Ellis Ross (American Fiction), Bowen Yang (Saturday Night Live), Abbi Jacobson (Broad City), Jay Ellis (Top Gun: Maverick), Andrew Dismukes (Saturday Night Live), Lennon Parham (Minx), Gary Anthony Williams (Night Court), and John Waters (Hairspray) will appear in the first season, which premieres on February 23.

They join previously announced series regulars Maya Rudolph, Natasha Lyonne, Keke Palmer, Stephanie Hsu, Sam Smith and Kieran Culkin, who will be joined by his real-life brothers Macaulay, Rory, Christian and Shane Culkin.

Created by Dunlap, The Second Best Hospital in the Galaxy follows Dr. Sleech (Hsu) and Dr. Klak (Palmer) —aliens, best friends, and intergalactically renowned surgeons—as they tackle anxiety-eating parasites, illegal time loops, and deep-space STIs. In Season 1, doctors Sleech and Klak take on a highly dangerous and potentially groundbreaking case and, in doing so, put existence itself in jeopardy. Although considering their dismal personal lives, oblivion might be an improvement.

Dunlap also serves as showrunner, writer, and executive producer, along with EPs Rudolph, Animal Pictures’ Behrens and Lyonne, Shauna McGarry, Shannon Prynoski, Chris Prynoski, Antonio Canobbio and Titmouse’s Ben Kalina. Artist and animator Robin Eisenberg will co-produce and serve as production designer.

Watch the trailer above.